O-Toluidine → 2,6-Bis[1-(2-methylphenylimino)ethyl]pyridine

HRID 1593713Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1593713
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](=O)[CH3:11])[N:5]=1)(=O)[CH3:2].[NH2:13][C:14]1[C:15]([CH3:20])=[CH:16][CH:17]=[CH:18][CH:19]=1>C(O)=O.C(Cl)Cl>[CH3:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[N:13]=[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](=[N:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])[CH3:11])[N:5]=1)[CH3:2]

Komponenten

5

Edukt 2

HCID 7242O-ToluidineHCID 707902,6-Diacetylpyridine

Produkt 1

HCID 112719622,6-Bis[1-(2-methylphenylimino)ethyl]pyridineAusbeute 45,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 284Formic AcidKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

One g of 2,6-diacetylpyridine and 3.0 ml of o-toluidine were added to an Erlenmeyer flask with 20 ml of methylene chloride. A stirbar and 5 drops of 97% formic acid were added, and the flask was sealed and the solution was stirred for 40 hours. The solvent was then removed in vacuo, and the flask was placed in the freezer at −30° C. The resulting viscous oil was washed with cold methanol, and a yellow solid formed and was isolated by filtration and identified by 1H NMR as the desired product (959 mg, 45.9%). 1H NMR (CDCl3): δ 8.38 (d, 2, Hpyr), 7.86 (t, 1, Hpyr), 7.20 (m, 4, Haryl) 7.00 (t, 2, Haryl) 6.67 (d, 2, Haryl), 2.32 (s, 6, N═CC—CH3), 2.10 (s, 6, CH3 aryl).

Aufarbeitung

  1. customthe flask was sealed
  2. customThe solvent was then removed in vacuo
  3. customwas placed in the freezer at −30° C
  4. washThe resulting viscous oil was washed with cold methanol
  5. customa yellow solid formed
  6. customwas isolated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-cfc068826202476bb08fbc5dde3f8a3c
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07297806B2

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