Hydrochloric Acid → 2-[4-(Dimethylamino)phenyl]-2-methylpropanoic acid

HRID 1594686Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1594686
[CH3:1][N:2]([CH3:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:16])([CH3:15])[C:10]([O:12]CC)=[O:11])=[CH:5][CH:4]=1.[OH-].[Na+].Cl>C(O)C.O>[CH3:17][N:2]([CH3:1])[C:3]1[CH:4]=[CH:5][C:6]([C:9]([CH3:15])([CH3:16])[C:10]([OH:12])=[O:11])=[CH:7][CH:8]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57182128HCID 57182128, Verbindung

Produkt 1

HCID 206960032-[4-(Dimethylamino)phenyl]-2-methylpropanoic acidAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of ethyl (4-dimethylaminophenyl)-2,2-dimethylacetate (1.00 g, 4.25 mmol) and sodium hydroxide (0.85 g) in ethanol (20 mL) and water (9 mL) was heated under reflux for 18 hours. The mixture was cooled, acidified with 10% HCl, and washed with ethyl acetate. The aqueous phase was evaporated. The residue was dissolved in aqueous saturated sodium bicarbonate, and extracted with ethyl acetate. The organic phase was dried, filtered and evaporated to give (4-dimethylaminophenyl)-2,2-dimethylacetic acid as a faint red solid (0.81 g, 92%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. temperatureThe mixture was cooled
  4. washwashed with ethyl acetate
  5. customThe aqueous phase was evaporated
  6. dissolutionThe residue was dissolved in aqueous saturated sodium bicarbonate
  7. extractionextracted with ethyl acetate
  8. customThe organic phase was dried
  9. filtrationfiltered
  10. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3db31fa723aa4fbcaccbfa16e47f198f
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06284768B1

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