Dimethylamine, hydrochloride → N-(4-dimethylaminomethylphenylmethyl)acetamide

HRID 1595377

Reaktionsgleichung

Reaktionsgleichung von HRID 1595377
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1.Cl.[CH3:15][NH:16][CH3:17].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:15][N:16]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1)[CH3:17]

Komponenten

5

Edukt 3

HCID 10473Dimethylamine, hydrochlorideHCID 11430Potassium CarbonateHCID 15550682223512-41-2

Produkt 1

HCID 21703715N-(4-dimethylaminomethylphenylmethyl)acetamideAusbeute 136,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

N-(4-Chloromethylphenylmethyl)acetamide (20.0 g) and dimethylamine hydrochloride (9.1 g) were dissolved in acetonitrile (190 ml), and potassium carbonate (28 g) was added. The mixture was refluxed under heating overnight. An insoluble solid was filtered off and the solvent was evaporated to give the objective N-(4-dimethylaminomethylphenylmethyl)acetamide (28.4 g) as an oil.

Aufarbeitung

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating overnight
  3. filtrationAn insoluble solid was filtered off
  4. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-003b84edd6804181a283ab5e3d577154
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06288061B1

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