HCID 69949538, Verbindung → 4-CarboxyMethyl-cyclohexanecarboxylic acid ethyl ester
Reaktionsgleichung
[C:1]([O:5][C:6]([CH:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]([O:17]C(C)(C)C)=[O:16])[CH2:10][CH2:9]1)=[O:7])(C)(C)[CH3:2].[H][H]>[Pd].C(O)C>[CH2:1]([O:5][C:6]([CH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:17])=[O:16])[CH2:10][CH2:9]1)=[O:7])[CH3:2]Komponenten
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of diester (B) (12.5 g, 46.3 mmol) and 10% palladium on activated carbon (5 g) in absolute ethanol (200 mL) was exposed to a hydrogen atmosphere (at balloon pressure) and stirred vigorously for lh. After removal of catalyst by filtration and concentration, the resultant colorless oil was dissolved in methylene chloride (150 mL) and TEA (75 mL) and stirred for 15 min. All volatiles were removed by rotary evaporation and the resultant colorless oil placed under high vacuum to give (C) 4-carboxymethyl-cyclohexanecarboxylic acid ethyl ester (9.9 g, 99%) as a white solid. Data for cis/trans mixture: 1H NMR (400 MHz, CD3OD) δ 4.13 (2q, 4H), 2.58 (m, 1H), 2.30-2.20 (m, 1H), 2.20 (2d, 4H), 2.05-1.80 (m, 7H), 1.80-1.55 (m, 5H), 1.50-1.38 (m, 3H), 1.32-1.25 (m, 1H), 1.25 (2t, 6H), 1.10-1.00 (m, 2H); mass spectrum m/z 215 [(M+H)+; calcd for C11H19O4: 215].
Aufarbeitung
- customAfter removal of catalyst
- filtrationby filtration and concentration
- dissolutionthe resultant colorless oil was dissolved in methylene chloride (150 mL)
- stirringTEA (75 mL) and stirred for 15 min
- customAll volatiles were removed by rotary evaporation
Quellen und Nachweise
- ORD-Eintrag
- ord-0cfeea42171f47a9b846e3f55574e52b
- Quelldatensatz
- uspto-grants-2001_09
- Patentnummer
- US06291499B1
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