1-Chloro-4-morpholin-4-yl-2-naphthol → 4-Morpholino-2-naphthol

HRID 1596668

Reaktionsgleichung

Reaktionsgleichung von HRID 1596668
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:4][C:3]=1[OH:18]>[OH-].[Na+].C(O)C.[Pd]>[O:15]1[CH2:14][CH2:13][N:12]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH:2]=[C:3]([OH:18])[CH:4]=2)[CH2:17][CH2:16]1

Komponenten

5

Edukt 1

HCID 6096921-Chloro-4-morpholin-4-yl-2-naphthol

Produkt 1

HCID 109880424-Morpholino-2-naphtholAusbeute 77,8 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

in a 0.3 l steel autoclave, 10.5 g of 1-chloro-4-morpholino-2-naphthol in 150 ml of sodium hydroxide (2N) and 30 ml of ethanol are maintained under a pressure of 3 bar and at 35° C. in the presence of 3 g of palladium on charcoal (5%) for 7 hours. The solution is then filtered to remove the catalyst. The aqueous phase is then acidified with acetic acid and then filtered. The precipitate is washed with water and then dried. 7.1 g of 4-morpholino-2-naphthol are thus obtained.

Aufarbeitung

  1. filtrationThe solution is then filtered
  2. customto remove the catalyst
  3. filtrationfiltered
  4. washThe precipitate is washed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9097480114864321971c9a53acc09a4f
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06291561B1

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