Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile

HRID 1597264

Reaktionsgleichung

Reaktionsgleichung von HRID 1597264
Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH2:8]([N:15]1[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C-:22]#[N:23].[Na+]>CO.O>[CH2:8]([N:15]1[CH2:20][CH2:19][C:18]([C:22]#[N:23])([N:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]2)[CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

6

Edukt 3

HCID 8929Sodium CyanideHCID 192201-Benzyl-4-piperidoneHCID 2723721Piperidine, hydrochloride (1:1)

Produkt 1

HCID 27334341'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrileAusbeute 95,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

12.16 g of piperidine hydrochloride and 18.9 g of 1-benzylpiperid-4-one are dissolved in 50 ml of an MeOH/H20 mixture (50/50; v/v). 5.3 g of NaCN dissolved in 20 ml of water are added dropwise. After stirring for 48 hours, the precipitate formed is filtered, rinsed with water and dried to give 27 g of the expected product.

Aufarbeitung

  1. additionare added dropwise
  2. customthe precipitate formed
  3. filtrationis filtered
  4. washrinsed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c96c12078ae548d29d26a151cbb5c173
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06294537B1

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