4-Quinolinecarboxaldehyde → 1-(Quinolin-4-yl)ethanol

HRID 1597363Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1597363
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=[O:12])=[CH:3][CH:2]=1.[Li][CH3:14]>CCOCC>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:12])[CH3:14])=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 780724-QuinolinecarboxaldehydeHCID 178418348HCID 178418348, Verbindung

Produkt 1

HCID 53147551-(Quinolin-4-yl)ethanolAusbeute 64,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To 4-quinolinecarbaldehyde (2 g, 12.73 mmol) in 20 ml anhydrous ether, MeLi (1.4M, 10 ml, 13.9 mmol) was added dropwise over a period of five minutes at 0° C. The reaction mixture was stirred at room temperature tor 3 hours. The solution was partitioned between ether (20 ml) and water (10 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to give 1.43 g (59%) of the product which was then used as such for the subsequent step.

Aufarbeitung

  1. customThe solution was partitioned between ether (20 ml) and water (10 ml)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6eb32150d70c41e5ad6cbef956406831
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06294566B1

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