Bromine → 2-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one

HRID 1597609Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1597609
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1)=[O:11]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 27373251-(3-Fluoro-4-hydroxyphenyl)ethan-1-one

Produkt 1

HCID 179235302-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-oneAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (2.0 g, 12.98 mmol) in dioxane (3 ml) was added a solution of bromine (2.09 g, 13.1 mmol) in dioxane (12 ml), and the mixture was stirred for 16 hours. The mixture was concentrated in vacuo to give title compound (3.02 g, 99% yield). The compound was used for next reaction without purification.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1c1f14ced9ac4a34b39d23ba151dea33
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06294558B1

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