HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Methylindoline → 6,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazoline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Methylindoline | HCID 583703 | — |
| Edukt | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Produkt | 6,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazoline | HCID 18932799 | 94% |
Reaktionsschritte
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 94% yield from 4-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 174°-175° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.85 min.).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05736534 |
| Quelldatensatz | uspto-grants-1998_04 |
| ORD ID | ord-2f60dc0806f4460ab0297b10e7ff175f |
| Quellennotiz | uspto-grants-1998_04 |