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HRID1597929

反应详情

EQUATION

反应方程式

HRID 1597929 的结构方程式

REACTANTS

反应物

2
结构：Cc1cccc2c1CCN2
HCID583703

4-Methyl-2,3-dihydro-1H-indole

C9H11N

结构：COc1cc2ncnc(Cl)c2cc1OC
HCID2769364

4-Chloro-6,7-dimethoxyquinazoline

C10H9ClN2O2

PRODUCTS

生成物

1
结构：COc1cc2ncnc(N3CCc4c(C)cccc43)c2cc1OC
HCID18932799

未命名化合物

收率 94%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 94% yield from 4-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 174°-175° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.85 min.).