Water → 2-n-butyl sulfonylamino-5-[2-benzylpyridazin-3(2H)-on-6-yl]indane

HRID 1598570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1598570
C([S:5]([NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]3[CH:19]=[CH:20][C:21](=[O:24])[NH:22][N:23]=3)[CH:15]=2)[CH2:10]1)(=[O:7])=[O:6])CCC.C(=O)([O-])[O-].[K+].[K+].[CH2:31](Br)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.O>CN(C)C=O>[CH2:17]([CH:10]1[CH2:11][C:12]2[C:17](=[CH:16][CH:15]=[C:14]([C:18]3[CH:19]=[CH:20][C:21](=[O:24])[N:22]([CH2:31][C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[N:23]=3)[CH:13]=2)[CH:9]1[N:8]=[S:5](=[O:7])=[O:6])[CH2:9][CH2:10][CH3:11]

Komponenten

6

Edukt 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 189298022-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane

Produkt 1

HCID 867523882-n-butyl sulfonylamino-5-[2-benzylpyridazin-3(2H)-on-6-yl]indaneAusbeute 183,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To 1.0 g of 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane dissolved in 30 ml of dimethylformamide were added 828 mg of potassium carbonate and 547 mg of benzyl bromide, and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction mixture, and crude crystals precipitated were collected by filtration, dried and then recrystallized from ethanol to obtain 1.15 g of 2-n-butyl sulfonylamino-5-[2-benzylpyridazin-3(2H)-on-6-yl]indane. This compound had the same physical property values as those of the compound obtained in Example 85.

Aufarbeitung

  1. customcrude crystals precipitated
  2. filtrationwere collected by filtration
  3. customdried
  4. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-c3f5e7f4bcd545958751089cd53a1d39
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05739132

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