Chloroform → trans-2-Benzamido-cyclohexanol

HRID 1598787Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1598787
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[OH:8].C(Cl)(Cl)Cl.C(=O)(O)[O-].[Na+].[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O>[C:18]([NH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[OH:8])(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

6

Edukt 4

HCID 6212ChloroformHCID 7412Benzoyl chlorideHCID 516892Sodium BicarbonateHCID 735777(1R,2R)-2-Aminocyclohexanol

Produkt 1

HCID 11020385trans-2-Benzamido-cyclohexanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

(±)-trans-2-Aminocyclohexanol (241 gm) was combined with chloroform (2000 ml), water (2000 ml) and sodium bicarbonate (352 gm) and stirred. Benzoyl chloride (352 gm) was added dropwise to the stirred solution and stirring was continued for 1 hr. The product was filtered and washed with water. The white solid was dried at 80° C. to provide the product (mp 172°-173° C.).

Aufarbeitung

  1. stirringstirring
  2. filtrationThe product was filtered
  3. washwashed with water
  4. customThe white solid was dried at 80° C.

Quellen und Nachweise

ORD-Eintrag
ord-4c9df444ff4f41f995b0fcd92b94bc12
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05739158

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