Sulfuric Acid → 4-Chloro-2-fluoro-5-sulfamoylbenzoic acid

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Reaktionsgleichung

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](Cl)(Cl)Cl)=[C:4]([F:12])[CH:3]=1.[OH:13][S:14](Cl)(=O)=[O:15].S(=O)(=O)(O)[OH:19].[OH-:23].[NH4+:24]>>[Cl:1][C:2]1[C:7]([S:14](=[O:15])(=[O:13])[NH2:24])=[CH:6][C:5]([C:8]([OH:19])=[O:23])=[C:4]([F:12])[CH:3]=1

Komponenten

Edukt 4

HCID 1118Sulfuric Acid

HCID 14923Ammonium Hydroxide

HCID 24638Chlorosulfonic acid

HCID 189316154-Chloro-2-fluoro-1-(trichloromethyl)benzene

Produkt 1

HCID 124625724-Chloro-2-fluoro-5-sulfamoylbenzoic acid

Versuchsvorschrift

4-chloro-2-fluoro-benzotrichloride (III) obtained in step (A) is chlorosulfonylated by treatment with sulfuric chlorohydrin in the presence of sulfuric acid and the resulting product is ammonolyzed by treatment with ammonium hydroxide to give 4-chloro-2-fluoro-5-sulfamoyl-benzoic acid (IV);

Quellen und Nachweise

ORD-Eintrag: ord-0e15f147aa2947928872a1644447127e
Quelldatensatz: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05739361

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