2-Chlor-5-nitro-benzolsulfonylfluorid → 5-Amino-2-chlorobenzene-1-sulfonyl fluoride

HRID 1599206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1599206
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[S:11]([F:14])(=[O:13])=[O:12]>C(O)(=O)C.[Fe]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[S:11]([F:14])(=[O:12])=[O:13]

Komponenten

4

Edukt 1

HCID 543404312-Chlor-5-nitro-benzolsulfonylfluorid

Produkt 1

HCID 542778915-Amino-2-chlorobenzene-1-sulfonyl fluoride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

The 2-chloro-5-nitro benzene sulphonylfluoride (2.4 parts) was stirred. in glacial acetic acid (25 parts) with iron powder (2 parts). Heated to reflux and stirred at reflux for 2.5 hours, then cooled to room temperature, poured onto ice/water and allowed to stand at room temperature overnight. The resultant precipitate was filtered off and dried in air to yield the product 2-chloro-5-amino benzene sulphonylfluoride (0.8 parts).

Aufarbeitung

  1. temperatureHeated
  2. temperatureto reflux
  3. temperatureat reflux for 2.5 hours
  4. additionpoured onto ice/water
  5. filtrationThe resultant precipitate was filtered off
  6. customdried in air

Quellen und Nachweise

ORD-Eintrag
ord-d61bdd17c2804f5a80fda73eca223505
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05739299

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