HCID 53754201, Verbindung → Ethyl 6-amino-1H-benzimidazole-2-acetate

HRID 1599468Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1599468
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1

Komponenten

4

Edukt 1

HCID 53754201HCID 53754201, Verbindung

Produkt 1

HCID 54171359Ethyl 6-amino-1H-benzimidazole-2-acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 5-nitrobenzimidazole-2-acetate (206 mg, 0.83 mmol, 1 equiv.), 10% palladium on carbon (88 mg, 0.08 mmol, 0.1 equiv.), and absolute ethanol (8 mL) was stirred at room temperature under hydrogen (balloon). After 45 minutes, the reaction was filtered through Celite®, and the filtrate was concentrated to afford crude ethyl 5-aminobenzimidazole-2-acetate. This was used without further purification.

Aufarbeitung

  1. filtrationthe reaction was filtered through Celite®
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-943e802d0a5a4a16a2ed835d1e0a965d
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05741804

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