Chlorosuccinimide → 3-(5-Chloro-2,3-dihydro-benzofuran-4-yl)propylamine hydrochloride

HRID 1602397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1602397
[ClH:1].[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][CH2:12][CH2:13][NH2:14])[C:5]=2[CH2:4][CH2:3]1.[Cl:15]N1C(=O)CCC1=O>C(O)(=O)C>[ClH:15].[Cl:1][C:9]1[CH:8]=[CH:7][C:6]2[O:2][CH2:3][CH2:4][C:5]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH2:14]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 196116703-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

Produkt 1

HCID 196116663-(5-Chloro-2,3-dihydro-benzofuran-4-yl)propylamine hydrochlorideAusbeute 91,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of of 3-(2,3-dihydro-benzofuran-4-yl)-propylamine hydrochloride (150 mg) and N-chlorosuccinimide (100 mg) in acetic acid (50 ml) was stirred at room temperature overnight. The solution was evaporated to dryness and the residue taken up in water, basified with 2N sodium hydroxide and extracted with dichloromethane. The extracts were dried and evaporated and the residue disolved in a solution of hydrogen chloride in methanol. Evaporation gave the the title compound (159 mg) as an off-white powder after trituration with ether.

Aufarbeitung

  1. customThe solution was evaporated to dryness
  2. extractionextracted with dichloromethane
  3. customThe extracts were dried
  4. customevaporated
  5. customEvaporation

Quellen und Nachweise

ORD-Eintrag
ord-63f4c3f878b44de49201f7f2c813e6b7
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05981572

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