2-(Dimethoxymethyl)-1,8-naphthyridine → 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

HRID 1602657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1602657
[CH3:1][O:2][CH:3]([O:14][CH3:15])[C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1>CO.[Pd]>[CH3:15][O:14][CH:3]([O:2][CH3:1])[C:4]1[CH:13]=[CH:12][C:11]2[CH2:10][CH2:9][CH2:8][NH:7][C:6]=2[N:5]=1

Komponenten

4

Edukt 1

HCID 177501752-(Dimethoxymethyl)-1,8-naphthyridine

Produkt 1

HCID 177501767-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution 14-1 (10 g, 0.049 mol) in MeOH, (100 ml) was treated with 10% Pd on C (1.5 g) and the resulting mixture stirred under a H2 filled balloon for 12.5 h. The catalyst was removed by filtration through celite and the solution concentrated to afford 14-2 as a yellow crystalline solid.

Aufarbeitung

  1. customThe catalyst was removed by filtration through celite
  2. concentrationthe solution concentrated

Quellen und Nachweise

ORD-Eintrag
ord-cbc23ace4cc84f0199e5556d3b5593a4
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05981546

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