HCID 19605759, Verbindung → 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

HRID 1603527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1603527
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]#[C:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][CH2:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]

Komponenten

4

Edukt 1

HCID 19605759HCID 19605759, Verbindung

Produkt 1

HCID 99490646-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

150 mg of 6-[2-(2,5-dimethoxyphenyl)ethynyl]-4-ethyl-quinazoline are dissolved in 10 ml of ethyl acetate. After addition of 20 mg of palladium (10% on charcoal) the mixture is stirred overnight under an atmosphere of hydrogen and subsequently filtered over celite. The filtrate is evaporated in vacuo and the residue crystallised from cylohexane to obtain the title compound as colourless crystals. mp: 74°.

Aufarbeitung

  1. filtrationsubsequently filtered over celite
  2. customThe filtrate is evaporated in vacuo
  3. customthe residue crystallised from cylohexane

Quellen und Nachweise

ORD-Eintrag
ord-cc9ba045d0294a579aae97e17a56de20
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05990116

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