Chloroform → 2-(4-Acetylphenoxy)-2-methylpropionic acid

HRID 1605118

Reaktionsgleichung

Reaktionsgleichung von HRID 1605118
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[OH-:11].[Na+].C(Cl)(Cl)Cl>CC(C)=O>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([O:1][C:5]([CH3:6])([CH3:4])[C:8]([OH:10])=[O:11])=[CH:3][CH:4]=1)(=[O:10])[CH3:9]

Komponenten

5

Edukt 3

HCID 6212ChloroformHCID 74694'-HydroxyacetophenoneHCID 14798Sodium Hydroxide

Produkt 1

HCID 1041062-(4-Acetylphenoxy)-2-methylpropionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g. of p-hydroxyacetophenone, 960 g. of sodium hydroxide and 715 g. of chloroform in 11 liters of acetone according to the procedure described above in Example 1, part (d). The product was recrystallized from carbon tetrachloride and from isopropyl acetate to give 2-(p-acetylphenoxy)-2-methylpropionic acid as a pale cream solid, m.p. 108°-110°C.

Aufarbeitung

  1. custom2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g
  2. customThe product was recrystallized from carbon tetrachloride and from isopropyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-43972321ca904c3ca0b13546863795ca
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03948973

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