Hydrochloric Acid → HCID 21546851, Verbindung

HRID 1605545Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1605545
[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([S:24](Cl)(=[O:26])=[O:25])[C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH-].[NH4+:30]>>[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([S:24](=[O:26])(=[O:25])[NH2:30])[C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 21546866HCID 21546866, Verbindung

Produkt 1

HCID 21546851HCID 21546851, Verbindung

Versuchsvorschrift

3-Benzylamino-5-chlorosulfonyl-4-phenylbenzoic acid (1.0 g) is in portions added to conc. ammonium hydroxide (10 ml) while stirring at 10°-12° C. After additional stirring at room temperature for about 18 hours, the resulting solution is dropwise added to an excess of icecold 4 N hydrochloric acid. The resulting precipitate is collected by filtration, washed with water and dried. After recrystallization from aqueous ethanol, 3-benzylamino-4-phenyl-5-sulfamylbenzoic acid is obtained with a melting point of 221°-222° C.

Aufarbeitung

  1. stirringAfter additional stirring at room temperature for about 18 hours
  2. filtrationThe resulting precipitate is collected by filtration
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization from aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-b10c56a25f4744ae9a63c6555c207773
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03950380

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