2,6-Dimethylaniline → N-(2',6'-dimethylphenyl)-1-methoxymethylethylamine

HRID 1606267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1606267
[NH2:1][C:2]1[C:3]([CH3:9])=[CH:4][CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:10][O:11][CH2:12][CH:13](OS(C1C=CC(C)=CC=1)(=O)=O)[CH3:14]>C1(C)C=CC=CC=1.CCOCC>[CH3:10][O:11][CH2:12][CH:13]([NH:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9])[CH3:14]

Komponenten

5

Edukt 2

HCID 68962,6-DimethylanilineHCID 1270077423946-74-9

Produkt 1

HCID 10899497N-(2',6'-dimethylphenyl)-1-methoxymethylethylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 484 g (4 mole) of 2,6-xylidine and 490 g (2 mole) of p-toluenesulphonic acid-(1-methoxyprop-2-yl)-ester in 1000 ml of toluene is refluxed for 25 hours. The reaction mixture is cooled, then made alkaline and diluted with ether. The organic phase is repeatedly washed with water and dried with magnesium sulphate. Evaporation of the solvent and subsequent distillation of the residue yields the desired N-(1-methoxyprop-2-yl)-2,6-xylidine with a boiling point of 70°-72°C/0.4 Torr.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled
  2. washThe organic phase is repeatedly washed with water
  3. dry with materialdried with magnesium sulphate
  4. customEvaporation of the solvent and subsequent distillation of the residue

Quellen und Nachweise

ORD-Eintrag
ord-5d435b69e1b04433ae4ed8e4a39b7333
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03952056

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