Sodium Chloride → 4-Benzoyl-2,3-dihydro-1H-inden-1-one

HRID 1606718Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1606718
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][C:17]([OH:19])=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[Cl-].[Na+]>O>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:10]=1[CH2:15][CH2:16][C:17]2=[O:19])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 5234Sodium ChlorideHCID 6451240Aluminum(III) ChlorideHCID 12286997Benzenepropanoic acid, 2-benzoyl-

Produkt 1

HCID 131930944-Benzoyl-2,3-dihydro-1H-inden-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

Five g. of o-benzoyl-β-phenylpropionic acid, 13 g. of anhydrous aluminum chloride and 1.3 g. of sodium chloride are admixed together and heated at 160°C for 1 hour. After cooling, water is added to the mixture, followed by extraction with chloroform. The extract is washed with a 5 % aqueous solution of sodium bicarbonate and water in that order and, then, dried. The solvent is distilled off under reduced pressure and the residue is dissolved in ethanol. The solution is decolorized with activated carbon and recrystallized from ethanol. The procedure yields 4-benzoylindan-1-one as crystals melting at 86°-88°C.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionfollowed by extraction with chloroform
  3. washThe extract is washed with a 5 % aqueous solution of sodium bicarbonate and water in that order
  4. customdried
  5. distillationThe solvent is distilled off under reduced pressure
  6. dissolutionthe residue is dissolved in ethanol
  7. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3e617f3e9cc742f38adf3420db637316
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03953500

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