Phenyl glycidyl ether → 1-Phenoxy-2-propanol

HRID 1606792

Reaktionsgleichung

Reaktionsgleichung von HRID 1606792
CC(C1C(O)=CC=CC=1O)=O.[C:12]1([O:18][CH2:19][CH:20]2[O:22][CH2:21]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].C([N+](C)(C)C)C1C=CC=CC=1>C(OCCO)C>[OH:22][CH:20]([CH2:19][O:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:21]

Komponenten

5

Edukt 3

HCID 31217Phenyl glycidyl etherHCID 66854Benzyltrimethylammonium hydroxideHCID 696872',6'-Dihydroxyacetophenone

Produkt 1

HCID 928391-Phenoxy-2-propanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8076Glycol monoethyl etherLösungsmittel

Versuchsvorschrift

A solution of 2,6-dihydroxyacetophenone (15.2g.), phenylglycidyl ether (15.0 g) and benzyltrimethylammonium hydroxide (5 drops of a 40% solution) in 2-ethoxyethanol (75 ml) was heated under reflux for 48 hours. The solvent was removed under reduced pressure and the resulting solid was washed with ether. Recrystallization from aqueous ethanol gave 1-(2-acetyl-3-hydroxyphenoxy(-2-hydroxy-3-phenoxypropane, 19.0 g, as pale lemon needles, m.p. 100.5°-101.5° C.

Aufarbeitung

  1. temperatureunder reflux for 48 hours
  2. customThe solvent was removed under reduced pressure
  3. washthe resulting solid was washed with ether
  4. customRecrystallization from aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-4c190907babd413c942a9bdef2d33127
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03953604

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