HCID 131710167, Verbindung → H-Glu(OtBu)-Ser(tBu)-OtBu

HRID 1606828Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1606828
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:16][O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]>[Pd]>[NH2:1][C@H:2]([C:12]([NH:14][C@H:15]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:16][O:17][C:18]([CH3:20])([CH3:19])[CH3:21])=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:9])[CH3:10]

Komponenten

3

Edukt 1

HCID 131710167HCID 131710167, Verbindung

Produkt 1

HCID 10916435H-Glu(OtBu)-Ser(tBu)-OtBuAusbeute 83,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

2.5 g. of palladium-on-carbon are added to the solution of 17.2 g. (32 mmoles) of Z-30-31-OtBu in 350 ml. of methanol, and gaseous hydrogen is bubbled into the mixture for 1 hour. The catalyst is removed by filtration, the filtrate is evaporated to dryness under reduced pressure, the solid residue is mixed with petroleum ether, and the mixture is filtered. 10.97 g. (83.4 %) of H-Glu(OtBu)-Ser(tBu)-OtBu are obtained. M.p.: 78°-82° C, Rf11 = 0.4.

Aufarbeitung

  1. customof methanol, and gaseous hydrogen is bubbled into the mixture for 1 hour
  2. customThe catalyst is removed by filtration
  3. customthe filtrate is evaporated to dryness under reduced pressure
  4. additionthe solid residue is mixed with petroleum ether
  5. filtrationthe mixture is filtered

Quellen und Nachweise

ORD-Eintrag
ord-055ca1749ad24418b3d46b93683aecd7
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03953415

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