Isophthaloyl chloride → HCID 178476350, Verbindung

HRID 1607327Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1607327
[C:1]([O:4][CH2:5][C@H:6]1[O:10][C@@H:9]([N:11]2[CH:18]=[C:17]([F:19])[C:15](=[O:16])[NH:14][C:12]2=[O:13])[CH2:8][C@@H:7]1[O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:3])[CH3:2].[C:28](Cl)(=[O:38])[C:29]1[CH:37]=[CH:36][CH:35]=[C:31]([C:32](Cl)=[O:33])[CH:30]=1.C(N(CC)CC)C.[OH:47][C:48]1[CH:53]=[CH:52][NH:51][C:50](=[O:54])[CH:49]=1>O1CCOCC1>[C:1]([O:4][CH2:5][C@H:6]1[O:10][C@@H:9]([N:11]2[CH:18]=[C:17]([F:19])[C:15](=[O:16])[N:14]([C:28](=[O:38])[C:29]3[CH:37]=[CH:36][CH:35]=[C:31]([C:32]([O:47][C:48]4[CH:53]=[CH:52][N:51]=[C:50]([OH:54])[CH:49]=4)=[O:33])[CH:30]=3)[C:12]2=[O:13])[CH2:8][C@@H:7]1[O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:3])[CH3:2]

Komponenten

6

Edukt 4

HCID 7451Isophthaloyl chlorideHCID 8471Triethylamine2×HCID 136874845'-O-acetyl-3'-O-benzyl-2'-deoxy-5-fluorouridineHCID 546960044-Hydroxy-2(1H)-pyridinone

Produkt 1

HCID 178476350HCID 178476350, VerbindungAusbeute 30,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3.00 g of 5'-O-acetyl-3'-O-benzyl-2'-deoxy-5-fluorouridine in 100 ml of dry dioxane were added 2.40 g of isophthaloyl chloride and 8.5 ml of triethylamine, and the mixture was refluxed for 2 hours. Then, to the reaction mixture were added a suspension of 1.77 g of 4-hydroxy-2(1H)-pyridone and 9.60 ml of triethylamine in 100 ml of dry dioxane, and the mixture was refluxed for 2 hours. The insolubles were removed by filtration and the filtrate was concentrated. The residue was dissolved in 100 ml of ethyl acetate, and the solution was washed twice with 30 ml of saturated aqueous solution of sodium chloride. The ethyl acetate layer was dried on anhydrous sodium sulfate and concentrated. The residue was placed on a silica gel column to conduct a gradient elution using chloroform and mixtures of methanol (up to 2%) and chloroform. The fractions corresponding to the title compound were collected and concentrated to dryness, giving 1.48 g of the title compound as a powder in a yield of 30%.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 2 hours
  2. additionThen, to the reaction mixture were added
  3. temperaturethe mixture was refluxed for 2 hours
  4. customThe insolubles were removed by filtration
  5. concentrationthe filtrate was concentrated
  6. dissolutionThe residue was dissolved in 100 ml of ethyl acetate
  7. washthe solution was washed twice with 30 ml of saturated aqueous solution of sodium chloride
  8. dry with materialThe ethyl acetate layer was dried on anhydrous sodium sulfate
  9. concentrationconcentrated
  10. washa gradient elution
  11. customThe fractions corresponding to the title compound were collected
  12. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-e004b8f04a3c423e8528fb798b090b76
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04864021

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