Morpholine → 4-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

HRID 16074

Reaktionsgleichung

Reaktionsgleichung von HRID 16074
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15](Cl)(=[O:17])=[O:16])=[C:10]([F:19])[CH:9]=1>ClCCl>[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:16])=[O:17])=[C:10]([F:19])[CH:9]=1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

Produkt 1

HCID 686063584-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Morpholine (0.16 ml) was added to a stirred solution of 4-bromo-2,5-difluoro-benzenesulfonyl chloride (0.18 g) in dichloromethane (6 ml) under nitrogen. The reaction mixture was stirred overnight and then quenched with water. The organic phase was dried (MgSO4) and concentrated in vacuo to give the sub-title compound as a white solid (200 mg).

Aufarbeitung

  1. customquenched with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-39a68fdc2cf342168e2bccff054cfd0b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737135B2

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