Formic Acid → 2'-(2,4-Difluorophenoxy)-4'-formylmethanesulfonanilide

HRID 1607684

Reaktionsgleichung

Reaktionsgleichung von HRID 1607684
[C:1]([C:3]1[CH:13]=[CH:12][C:6]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])=[C:5]([O:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])[CH:4]=1)#N.C(O)=[O:24]>[Ni]>[F:22][C:16]1[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=1[O:14][C:5]1[CH:4]=[C:3]([CH:1]=[O:24])[CH:13]=[CH:12][C:6]=1[NH:7][S:8]([CH3:11])(=[O:10])=[O:9]

Komponenten

4

Edukt 2

HCID 284Formic AcidHCID 10358871N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

Produkt 1

HCID 104041542'-(2,4-Difluorophenoxy)-4'-formylmethanesulfonanilide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 935NickelKatalysator

Versuchsvorschrift

A mixture of 4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide (1.5 g) and Raney's Nickel (1.5 g) in 75% formic acid (40 ml) was refluxed for 2 hours. The mixture was filtered and the filtrate was concentrated to dryness. The residue was recrystallized from ethanol to give pale yellow needles of 2'-(2,4-difluorophenoxy)-4'-formylmethanesulfonanilide (1.4 g).

Aufarbeitung

  1. temperaturewas refluxed for 2 hours
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated to dryness
  4. customThe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3e809afbf2f64fc6873e6e5c47611791
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04866091

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