2-Nitro-2-phenyl-1,3-propanediol → 2-Phenyl-1,3-propanediol

HRID 1608044

Reaktionsgleichung

Reaktionsgleichung von HRID 1608044
[N+]([C:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH2:7][OH:8])[CH2:5][OH:6])([O-])=O.[H][H]>[Pd].CO>[C:9]1([CH:4]([CH2:5][OH:6])[CH2:7][OH:8])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

5

Edukt 2

HCID 2243932-Nitro-2-phenyl-1,3-propanediolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 2541782-Phenyl-1,3-propanediol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

12 g. (0.06 mole) of 2-nitro-2-phenyl-1, 3-propanediol, 400 mg. of 5% palladium on calcium carbonate and 150 ml. of methanol are placed in a Parr hydrogenator bottle and reduced with hydrogen overnight. The mixture is filtered through Celite, concentrated to an oil and recrystallized from 30 ml. of toluene. The yield is 7.4 g. (80%) of product, M.P. 52°-4° C.

Aufarbeitung

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated to an oil
  3. customrecrystallized from 30 ml

Quellen und Nachweise

ORD-Eintrag
ord-dd8b2b0d25b54515aa678d53f4143dc4
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04868327

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