L-Leucine → Benzoyl-L-leucine

HRID 1608116

Reaktionsgleichung

Reaktionsgleichung von HRID 1608116
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[NH2:12][C@H:13]([C:18]([OH:20])=[O:19])[CH2:14][CH:15]([CH3:17])[CH3:16]>O>[C:1]([NH:12][C@H:13]([C:18]([OH:20])=[O:19])[CH2:14][CH:15]([CH3:17])[CH3:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6106L-LeucineHCID 7412Benzoyl chlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 853887Benzoyl-L-leucine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Benzoyl chloride (4.22 g, 0.030 mol) and 10% NaOH (12 ml, 0.030 mol) were added separately with vigorous stirring to a solution of L-leucine (3.94 g, 0.030 mol) in 150 ml of distilled water at ice bath temperature. The reaction was allowed to proceed at this temperature until the reaction mixture became clear (30 minutes); it was then extracted with ethyl acetate (2×100 ml). The aqueous layer was separated, acidified to pH 2 with 10% HCl, and extracted with ethyl acetate (3×50 ml). The ethyl acetate extract was dried over anhydrous sodium sulfate. After filtration, the filtrate was evaporated in vacuo to yield quantitative amount of N-benzoyl-L-leucine as a semi-solid which was used directly for the following step.

Aufarbeitung

  1. custom(30 minutes)
  2. extractionit was then extracted with ethyl acetate (2×100 ml)
  3. customThe aqueous layer was separated
  4. extractionextracted with ethyl acetate (3×50 ml)
  5. extractionThe ethyl acetate extract
  6. dry with materialwas dried over anhydrous sodium sulfate
  7. filtrationAfter filtration
  8. customthe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-912f71e291cb4ac7808649629e534e6a
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04870056

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