Cysteamine Hydrochloride → 2-Butylthiomorpholin-3-one
Reaktionsgleichung
[OH-].[K+].Cl.[NH2:4][CH2:5][CH2:6][SH:7].Br[CH:9]([CH2:15][CH2:16][CH2:17][CH3:18])[C:10](OCC)=[O:11]>C(O)C>[CH2:15]([CH:9]1[S:7][CH2:6][CH2:5][NH:4][C:10]1=[O:11])[CH2:16][CH2:17][CH3:18]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Potassium hydroxide (56 g) was added to a suspension of cysteamine, hydrochloride (56.6 g) in absolute ethanol (300 ml) followed by dropwise addition of ethyl 2-bromohexanoate (111.5 g). When the exothermic reaction ceased, the mixture was refluxed for 3 hours and filtered. Concentration of the filtrate in vacuo gave the title compound as a viscous oil which was used in the next step without purification.
Aufarbeitung
- customWhen the exothermic reaction
- temperaturethe mixture was refluxed for 3 hours
- filtrationfiltered
Quellen und Nachweise
- ORD-Eintrag
- ord-b51a1ad99e9941cf8c8b120aa41b65a1
- Quelldatensatz
- uspto-grants-1989_09
- Patentnummer
- US04870063
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