Ethyl Bromide → 4-Acetyl-4'-ethoxybiphenyl

Reaktionsgleichung

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:17](Br)[CH3:18].C(=O)([O-])[O-].[K+].[K+].C1(=O)CCCCC1>>[CH2:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1)[CH3:18]

Komponenten

Edukt 4

HCID 6332Ethyl Bromide

HCID 7967Cyclohexanone

HCID 11430Potassium Carbonate

HCID 103308064-(4-Acetylphenyl)phenol

Produkt 1

HCID 232504334-Acetyl-4'-ethoxybiphenyl

Versuchsvorschrift

A reaction vessel was charged with 230 g of 4-hydroxy-4'-acetylbiphenyl, 164 g of ethyl bromide, 276 g of potassium carbonate and 1.7 l of cyclohexanone. The mixture was reacted together under agitation for 3 hours at 65°-70° C. and then for 6 hours at 95°-100° C. The reaction liquid was filtered and the resultant solid matter was washed with benzene. The filtrate and the washing liquid were combined, washed with water and dried over Glauber's salt, The solvents were distilled off and the residue was recrystallized from a mixed solvent of acetone-methanol to obtain 4-ethoxy-4'-acetylbiphenyl.