Sodium → HCID 178444960, Verbindung

HRID 1609290

Reaktionsgleichung

Reaktionsgleichung von HRID 1609290
[NH:1]1[C:5]([CH:6]([O:8][C:9]2[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=2)[O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20](=[O:34])[C:21]2[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:23][CH:22]=2)[CH3:7])=[N:4][N:3]=[N:2]1.[Na:38]>CCOCC.C(O)C>[Na:38].[NH:4]1[C:5]([CH:6]([O:8][C:9]2[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=2)[O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20](=[O:34])[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:25][CH:26]=2)[CH3:7])=[N:1][N:2]=[N:3]1

Komponenten

5

Edukt 2

HCID 5360545SodiumHCID 178444959HCID 178444959, Verbindung

Produkt 1

HCID 178444960HCID 178444960, VerbindungAusbeute 92,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

In 30 ml of ether was dissolved 2.0 g of N-[2-[3-[1-(1H-tetrazol-5-yl)ethoxy]phenoxy]phenyl]-4-hexyloxybenzamide followed by addition of a solution of 90 mg of sodium in ethanol, and the mixture was concentrated in vacuo to dryness. After addition of isopropyl ether, the resulting foamy solid was pulverized, filtered and dried to give 1.9 g of the sodium salt as a white amorphous powder.

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo to dryness
  2. additionAfter addition of isopropyl ether
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d1a9acbae6d7492d8361972f84ec0462
Quelldatensatz
uspto-grants-1995_03
Patentnummer
US05399703

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