Bromine → 2-Bromo-1-cycloheptylethan-1-one

HRID 1609314Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1609314
[CH3:1][C:2]([CH:4]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:3].[Br:11]Br>CO>[CH:4]1([C:2]([CH2:1][Br:11])=[O:3])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 126763521-Cycloheptylethan-1-one

Produkt 1

HCID 218423502-Bromo-1-cycloheptylethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

An ice cold solution of 19.0 g of cycloheptyl methyl ketone in 100 ml of methyl alcohol was treated dropwise with 7 ml of bromine. After 5 min, the ice bath was removed and the reaction mixture was allowed to warm to room temperature. The reaction mixture was then diluted with 500 ml of water and extracted with ethyl ether (3×75 ml). The combined extracts were washed with saturated sodium bicarbonate, brine, dried (MgSO4) and condensed in vacuo to yield 29.9 g of bromomethyl cycloheptyl ketone as an oil.

Aufarbeitung

  1. customthe ice bath was removed
  2. additionThe reaction mixture was then diluted with 500 ml of water
  3. extractionextracted with ethyl ether (3×75 ml)
  4. washThe combined extracts were washed with saturated sodium bicarbonate, brine
  5. customdried
  6. custom(MgSO4) and condensed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1a813d8be7df472196973d82b5d1d702
Quelldatensatz
uspto-grants-1995_03
Patentnummer
US05399702

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