Aniline → 2-Aminophenyl-4-nitro-benzonitrile

HRID 1609855

Reaktionsgleichung

Reaktionsgleichung von HRID 1609855
Cl[C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CN1CCCC1=O.C(N(C(C)C)CC)(C)C>CCOC(C)=O>[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Komponenten

6

Edukt 4

HCID 6115AnilineHCID 13387N-methyl-2-pyrrolidoneHCID 81531DiisopropylethylamineHCID 1414012-Chloro-4-nitrobenzonitrile

Produkt 1

HCID 179479572-Aminophenyl-4-nitro-benzonitrileAusbeute 88,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Chloro-4-nitro-benzonitrile (Aldrich) (3.64 g, 20 mmol), aniline (2 mL, 22 mmol), 1-methyl-2-pyrollidinone (10 mL) and diisopropylethylamine (4 mL) were combined and heated to 120° under Ar for 18 h, cooler poured into EtOAc (150 mL), washed with H20 (3×50 mL) and satd aq NaCl (50 mL), dried (Na2SO4), concentrated, and the residue was triturated with hexane, filtered and the solid was washed with hexane and dried in vacuo to afford 4.23 g (88%) of the title compound as a light green solid. 1H NMR (400) MHz, δ: 8.45 (finely split doublet, 1), 8.19 (dd, 1), 7.48 (m,3), 7.28 (d,2), 7.06 (d,1), 6.96 (br s,1).

Aufarbeitung

  1. temperatureheated to 120° under Ar for 18 h
  2. washwashed with H20 (3×50 mL)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated
  5. customthe residue was triturated with hexane
  6. filtrationfiltered
  7. washthe solid was washed with hexane
  8. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5a79adfa8994446aaeb07317d99fe9e9
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06982270B1

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