Hydrazine hydrate (1:1) → 3-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

HRID 1610126Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1610126
F[C:2]1[C:9]([O:10][CH3:11])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1.O.[NH2:22][NH2:23]>C(O)C>[F:19][C:15]1[CH:14]=[C:13]([C:12]2[C:3]3[C:2](=[C:9]([O:10][CH3:11])[CH:8]=[C:5]([C:6]#[N:7])[CH:4]=3)[NH:23][N:22]=2)[CH:18]=[CH:17][CH:16]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 22260967HCID 22260967, Verbindung

Produkt 1

HCID 222608863-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 640 mg of 4-fluoro-3-(3-fluorobenzoyl)-5-methoxybenzonitrile in 6 ml ethanol was added 3 ml of hydrazine monohydrate at room temperature, followed by stirring at 70° C. for one day. The reaction mixture was evaporated, and the resulting crystals were collected by filtration. The crystals were sequentially washed with ethanol and diethyl ether, to give 590 mg of the title compound as colorless crystals.

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were sequentially washed with ethanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-1f9b237ae6b045a7b7f8695af8494f12
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06982274B2

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