Hydrochloric Acid → HCID 22258297, Verbindung

HRID 1610826Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1610826
FC1C=CC=CC=1C([O:6][C:7]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[F:31])=[CH:8][C:9]1[N:10](C(=O)C2C=CC=CC=2F)[C:11]([CH3:15])=[C:12]([CH3:14])[N:13]=1)=O.O.[ClH:37]>>[ClH:37].[CH3:14][C:12]1[N:13]=[C:9]([CH2:8][C:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[F:31])=[O:6])[NH:10][C:11]=1[CH3:15]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 695894172-[1-(2-Fluorobenzoyl)-4,5-dimethyl-1H-imidazol-2-yl]-1-(2-fluorophenyl)ethenyl 2-fluorobenzoate

Produkt 1

HCID 22258297HCID 22258297, VerbindungAusbeute 14 %

Versuchsvorschrift

12.97 g crude crude compound of Example V are refluxed 1.5 h in 200 ml concentrated hydrochloric acid. The mixture is cooled to rT and 200 mL water are added. The solution is extracted twice with toluene and the aqueous phase is concentrated under vacuum. The residue is stirred with ethanol, filtered, washed once with ethyl acetate and once with petrol ether and dried to yield 1.04 g (14% of th.) 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(2-fluorophenyl)ethanone hydrochloride.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. extractionThe solution is extracted twice with toluene
  3. concentrationthe aqueous phase is concentrated under vacuum
  4. filtrationfiltered
  5. washwashed once with ethyl acetate and once with petrol ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-860b4b6731194912bc23a629ca07c025
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06984646B2

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