Iodoethane → 5-ethyl-6,7-dihydro-1-benzofuran-4(5H)-one

HRID 1612161

Reaktionsgleichung

Reaktionsgleichung von HRID 1612161
[CH3:1][CH:2]1C(=O)C2C=CSC=2CC1.[O:12]1[C:16]2[CH2:17][CH2:18][CH2:19][C:20](=[O:21])[C:15]=2[CH:14]=[CH:13]1.C(I)C>>[CH2:1]([CH:19]1[C:20](=[O:21])[C:15]2[CH:14]=[CH:13][O:12][C:16]=2[CH2:17][CH2:18]1)[CH3:2]

Komponenten

4

Edukt 3

HCID 6340IodoethaneHCID 27335414,5,6,7-Tetrahydro-1-benzofuran-4-oneHCID 154115085-methyl-6,7-dihydro-1-benzothiophen-4(5H)-one

Produkt 1

HCID 221474575-ethyl-6,7-dihydro-1-benzofuran-4(5H)-one

Versuchsvorschrift

Following the procedure for the preparation of 5-methyl-6,7-dihydro-1-benzothiophen-4(5H)-one but substituting 6,7-dihydro-1-benzofuran-4(5H)-one and ethyl iodide and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 1.00, 1.54, 1.95, 2.29, 2.91, 6.67, 7.3; MS (EI) m/z (rel. intensity) 164 (M+, 36), 164 (36), 136 (90), 135 (24), 108 (76), 88 (13), 86 (69), 84 (99), 80 (58), 52 (21), 51 (57). HRMS (FAB) calcd for C10H12O2+H 165.0916, found 165.0919. Anal. Calcd for C10H12O2: C, 73.15; H, 7.37. Found: C, 72.81; H, 7.60.

Quellen und Nachweise

ORD-Eintrag
ord-0d68b60a105a4e8bb10cb2f003a779aa
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06992087B2

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