Iodoethane → 2-Ethyl-6-methoxyindan-1-one
Reaktionsgleichung
C(C1[C:12](=[O:13])C2C=CSC=2CC1)CC.[CH3:14][O:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22](=O)[CH2:21][CH2:20][CH2:19]2.C(I)C>>[CH2:20]([CH:21]1[CH2:22][C:23]2[C:18](=[CH:17][C:16]([O:15][CH3:14])=[CH:25][CH:24]=2)[C:12]1=[O:13])[CH3:19]Komponenten
4
Versuchsvorschrift
Following the procedure for the preparation of 5-propyl-6,7-dihydro-1-benzothiophen-4(5H)-one but substituting 6-methoxy 1-tetralone and ethyl iodide, and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 1.02, 1.55, 1.99, 2.68, 2.77, 3.27, 3.86, 7.21, 7.37; HRMS (FAB) calcd for C12H14O2+H 191.1072, found 191.1075.
Quellen und Nachweise
- ORD-Eintrag
- ord-f1de98454b9b4a22b85de92a13af9590
- Quelldatensatz
- uspto-grants-2006_01
- Patentnummer
- US06992087B2
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