Hydrochloric Acid → HCID 69587003, Verbindung

Reaktionsgleichung

C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][C:16](=[O:32])[N:17]([CH3:31])[C@@H:18]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:19][N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)(C)(C)C.[ClH:34]>CO.CCOCC>[ClH:34].[ClH:34].[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][C:16]([N:17]([CH3:31])[C@@H:18]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:19][N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)=[O:32]

Komponenten

Versuchsvorschrift

To a stirring solution of 7a in methanol (0.1 M) at 0° C. was added a solution of hydrochloric acid (5.5 eq) in ether (2.0 M). The reaction was stirred at room temperature overnight. The methanol was removed under reduced pressure and the resulting crystals were triturated with ether, filtered off and dried to afford a white solid. (99%) 1H NMR (400 MHz, DMSO-d6) δ 10.91 (br s, 1H), 8.21 (br s, 2H), 7.26-7.54 (m, 9H), 6.15 (m, 1H), 3.79-4.32 (m, 9H), 3.65 (m, 2H), 3.54 (m, 1H), 3.16 (m, 3H), 2.94 (s, 3H). Mass Spectral Analysis m/z=352.3 (M+H)+ tR=3.44 min (97%)