Lithium Hydroxide → 3-(2-Oxo-1,3-oxazolidin-3-yl)benzoic acid

HRID 1612442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1612442
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]2[CH2:14][CH2:13][O:12][C:11]2=[O:15])[CH:5]=1.[Li+].[OH-]>O1CCOCC1>[O:15]=[C:11]1[N:10]([C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:16])=[O:2])[CH2:14][CH2:13][O:12]1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 695897133-(2-Oxooxazolidin-3-yl)benzoic Acid Methyl Ester

Produkt 1

HCID 222530423-(2-Oxo-1,3-oxazolidin-3-yl)benzoic acidAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3-(2-Oxooxazolidin-3-yl)benzoic acid methyl ester (D118) (110 mg, 0.5 mmol) in dioxane (2.5 ml) was treated with 1M LiOH solution (0.75 ml) and the mixture was stirred at room temperature for 1.5 h. Amberlyst 15 was then added and stirring continued for 15 mins. The resin was filtered and the filtrate evaporated to dryness. Th residue was tritutated with diethyl ether to afford the title compound (62 mg, 60%).

Aufarbeitung

  1. additionAmberlyst 15 was then added
  2. stirringstirring
  3. waitcontinued for 15 mins
  4. filtrationThe resin was filtered
  5. customthe filtrate evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-e46ad5cceda64c598328ea23b390abf7
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06992103B2

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