Sodium Methoxide → 2-(2,4-Difluorophenyl)-4-(3-trifluoromethylphenyl)-5-meth anesulfonylpyrimidine

HRID 1612565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1612565
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9]N(C)C)=O.Cl.[F:23][C:24]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:25]=1[C:26]([NH2:28])=[NH:27].C[O-].[Na+]>CO>[F:23][C:24]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:25]=1[C:26]1[N:28]=[C:6]([C:5]2[CH:17]=[CH:18][CH:19]=[C:3]([C:2]([F:1])([F:20])[F:21])[CH:4]=2)[C:8]([S:13]([CH3:16])(=[O:14])=[O:15])=[CH:9][N:27]=1

Komponenten

5

Edukt 3

HCID 10942334Sodium MethoxideHCID 200809312,4-Difluoro-benzamidine hydrochlorideHCID 541640061-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)ethene

Produkt 1

HCID 150368532-(2,4-Difluorophenyl)-4-(3-trifluoromethylphenyl)-5-meth anesulfonylpyrimidineAusbeute 77,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6 g of 1-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)ethene and 4.6 g of 2,4-difluorobenzamidine hydrochloride were dissolved in 30 ml of methanol at room temperature and 1.2 g of sodium methoxide was added thereto. The resulting mixture was heated under reflux for an hour. The solvent was distilled away under reduced pressure. The residue was washed with water and then dried to obtain 6 g of 2-(2,4-difluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine (Compound 147).

Aufarbeitung

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for an hour
  3. distillationThe solvent was distilled away under reduced pressure
  4. washThe residue was washed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-33c9126b8e454fc284e0bf771dea63fa
Quelldatensatz
uspto-grants-1993_03
Patentnummer
US05190575

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