Water → N-(2,3-Dihydro-1H-inden-2-yl)formamide

HRID 1612892Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1612892
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](O)(=[O:13])C.C(OC=O)=O.O>O1CCCC1>[CH:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)=[O:13]

Komponenten

5

Edukt 3

HCID 962WaterHCID 763102-AminoindaneHCID 86740153HCID 86740153, Verbindung

Produkt 1

HCID 14835235N-(2,3-Dihydro-1H-inden-2-yl)formamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a solution of 2-aminoindan (19.95 g) in tetrahydrofuran is added an solution of 2M acetic acid-formic acid anhydride in tetrahydrofuran under ice cooling, and the mixture is reacted at room temperature. To the reaction mixture is added water, and then, the solvent is distilled off, and the residue is extracted with ethyl acetate. After distilling off the solvent, the residue is recrystallized from ethyl acetate - n-hexane to give 2-formylaminoindan (19.02 g).

Aufarbeitung

  1. customthe mixture is reacted at room temperature
  2. distillationthe solvent is distilled off
  3. extractionthe residue is extracted with ethyl acetate
  4. distillationAfter distilling off the solvent
  5. customthe residue is recrystallized from ethyl acetate - n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-ac733324afe24761bce9d742b143df13
Quelldatensatz
uspto-grants-1993_03
Patentnummer
US05190975

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