Thioacetamide → HCID 19775571, Verbindung

HRID 1613230Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1613230
Cl[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)[C:3](=O)[CH3:4].[C:16]([NH2:19])(=[S:18])[CH3:17]>C(O)C.CCCCC>[CH3:17][C:16]1[S:18][C:2]([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)=[C:3]([CH3:4])[N:19]=1

Komponenten

5

Edukt 2

HCID 2723949ThioacetamideHCID 19775550HCID 19775550, Verbindung

Produkt 1

HCID 19775571HCID 19775571, VerbindungAusbeute 68,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8003PentaneLösungsmittel

Versuchsvorschrift

4.7 g of 3-chloro-4-(4-nitrophenyl)butan-2-one and 2.4 g of thioacetamide are dissolved in 60 ml of ethanol and refluxed for 12 hours. The reaction medium is concentrated, the residue is taken up in water and the solution is rendered basic with sodium carbonate and extracted with chloroform. After concentration of the organic phase, the solid obtained is taken up in hot pentane to give 3.5 g of 2,4-dimethyl-5-(4-nitrobenzyl)thiazole in the form of yellow crystals melting at 66° C.

Aufarbeitung

  1. temperaturerefluxed for 12 hours
  2. concentrationThe reaction medium is concentrated
  3. extractionextracted with chloroform
  4. customAfter concentration of the organic phase, the solid obtained

Quellen und Nachweise

ORD-Eintrag
ord-3a57211ae5f14641b84657733032337c
Quelldatensatz
uspto-grants-1993_03
Patentnummer
US05192781

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