Triethylamine → Naphthalen-2-yl sulfamate

HRID 1613788Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1613788
Cl[S:2]([N:5]=C=O)(=[O:4])=[O:3].[CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][C:9]=1[OH:18].C(N(CC)CC)C>C(#N)C.C(OCC)(=O)C.O>[CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][C:9]=1[O:18][S:2](=[O:3])(=[O:4])[NH2:5]

Komponenten

7

Edukt 3

HCID 8471TriethylamineHCID 86632-NaphtholHCID 70918Chlorosulfonyl isocyanate

Produkt 1

HCID 21149346Naphthalen-2-yl sulfamateAusbeute 107,5 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittel2×HCID 6342AcetonitrileLösungsmittel3×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a cold (ice-acetone bath) solution of 11.3 ml (0.13 mole, 18.4 g) of chlorosulfonyl isocyanate in 50 ml of acetonitrile was added dropwise a solution of 2.3 g (0.13 mole) of water in 10 ml of acetonitrile at such a rate that the temperature was maintained between -2° to 7° C. (ca. 45 min). After the addition was complete, the solution was stirred for 5 min and then treated dropwise with a solution of 14.4 g (0.1 mole) of β-naphthol, 20.9 ml (0.15 mole, 15.2 g) of triethylamine and 100 ml of acetonitrile at such a rate that the temperature did not exceed 10° C. (ca. 30 min). The mixture was stirred at ambient temperature for 3.5 h and then diluted with 100 of ethyl acetate and 50 ml of water. The layers were separated and the organic layer was washed once with 50 ml of water and once with 100 ml of brine, dried (sodium sulfate), and concentrated to give 24 g of dark gum. The gum was purified by column chromatography on 400 g of silica gel eluted with methylene chloride. Fractions containing the desired product were combined and concentrated to yield 5.7 g (26%) of the title compound as a white solid, mp 114°-115° C. (benzene).

Aufarbeitung

  1. temperaturewas maintained between -2° to 7° C. (ca. 45 min)
  2. additionAfter the addition
  3. customdid not exceed 10° C.
  4. custom(ca. 30 min)
  5. stirringThe mixture was stirred at ambient temperature for 3.5 h
  6. customThe layers were separated
  7. washthe organic layer was washed once with 50 ml of water and once with 100 ml of brine
  8. dry with materialdried (sodium sulfate)
  9. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7ec3e5585e0e44649f89f360899132df
Quelldatensatz
uspto-grants-1993_03
Patentnummer
US05194446

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