Trifluoroacetic acid → HCID 178480378, Verbindung

HRID 1614063Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1614063
[I-].C(OC([NH:9][C@@H:10]1[C:40](=[O:41])[N:12]2[C:13]([C:24]([O:26]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:25])=[C:14]([CH2:17][N+:18]3[N:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)[CH2:15][S:16][C@H:11]12)=O)(C)(C)C.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.C(OC(C)C)(C)C>C(Cl)Cl>[NH2:9][C@@H:10]1[C:40](=[O:41])[N:12]2[C:13]([C:24]([O-:26])=[O:25])=[C:14]([CH2:17][N+:18]3[N:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)[CH2:15][S:16][C@H:11]12

Komponenten

6

Edukt 4

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 7914Diisopropyl EtherHCID 178480376HCID 178480376, Verbindung

Produkt 1

HCID 178480378HCID 178480378, VerbindungAusbeute 176,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of benzhydryl 7β-tert-butoxycarbonylamino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide (22.3 g) and anisole (22 ml) in methylene chloride (66 ml) was added trifluoroacetic acid (44 ml) under ice-cooling. After the mixture was stirred at ambient temperature for an hour, the reaction mixture was added dropwise to diisopropyl ether (600 ml). The resultant precipitates were collected by filtration to give bis(trifluoroacetic acid) salts of 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (16.83 g).

Aufarbeitung

  1. temperaturecooling
  2. customThe resultant precipitates
  3. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-18051330a6104fa39a3890831faaa6be
Quelldatensatz
uspto-grants-1993_03
Patentnummer
US05194432

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