Water → HCID 59633913, Verbindung

HRID 1615061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1615061
[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([O:9][CH3:10])[CH:3]=1.C([O-])([O-])=O.[K+].[K+].[CH2:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Cl)=[CH:21][CH:20]=1)[CH3:18].O>CN(C=O)C>[CH2:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23][O:8][C:5]2[CH:6]=[CH:7][C:2]([I:1])=[CH:3][C:4]=2[O:9][CH3:10])=[CH:21][CH:20]=1)[CH3:18]

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 738434-Ethylbenzyl chlorideHCID 101061274-Iodo-2-methoxyphenol

Produkt 1

HCID 59633913HCID 59633913, VerbindungAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of 4-iodo-2-methoxyphenol (90 g) in DMF (450 mL) were added K2CO3 (60 g) and 4-ethylbenzyl chloride (58 g) at RT. The reaction mixture was stirred at 80° C. for 3 hr. Water (900 mL) was added to the reaction mixture. The precipitated solid was collected on a filter and dried under reduced pressure. The suspension of this solid in heptane (520 mL) was stirred at RT. The precipitated solid was collected on a filter and dried under reduced pressure to give the title compound (115 g, 87%).

Aufarbeitung

  1. customThe precipitated solid was collected on
  2. filtrationa filter
  3. customdried under reduced pressure
  4. additionThe suspension of this solid in heptane (520 mL)
  5. stirringwas stirred at RT
  6. customThe precipitated solid was collected on
  7. filtrationa filter
  8. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b974f25500f94a3a8049a6ef4e19be96
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765739B2

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