Hydrogen Peroxide → HCID 59634007, Verbindung

HRID 1615088Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1615088
[Si:1]([O:8][CH2:9][C:10]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)([F:12])[F:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[OH:19]O.O>C(Cl)(Cl)Cl.C[Re](=O)(=O)=O.[O-2].[Mn+4].[O-2]>[Si:1]([O:8][CH2:9][C:10]([C:13]1[CH:18]=[CH:17][N+:16]([O-:19])=[CH:15][CH:14]=1)([F:12])[F:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Komponenten

7

Edukt 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 59633930HCID 59633930, Verbindung2×

Produkt 1

HCID 59634007HCID 59634007, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 178477782HCID 178477782, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 4-[2-(tert-butyldimethylsilanyloxy)-1,1-difluoroethyl]pyridine (0.14 g) prepared in (3) in chloroform (3 mL) were added methyltrioxorhenium (VII) (0.0010 g) and aqueous 30% hydrogen peroxide (0.11 mL). The reaction mixture was stirred at RT for 4 hr. To the mixture was added manganese (IV) oxide. The reaction mixture was stirred at RT for 1 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was dried over MgSO4. The solvent was removed under reduced pressure to give the crude title compound.

Aufarbeitung

  1. stirringThe reaction mixture was stirred at RT for 1 hr
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialThe organic layer was dried over MgSO4
  4. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2bb54548753147d6be282a2d499fa580
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765739B2

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