Water → Imidazo(1,2-a)pyridine-2-carbaldehyde
Reaktionsgleichung
[N:1]1[C:2]([CH2:10][OH:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.O>CCO.[O-2].[Mn+4].[O-2]>[N:1]1[C:2]([CH:10]=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of imidazo[1,2-a]pyridin-2-ylmethanol (3.0 g, 20 mmol) in EtOH (50 mL) was added manganese (IV) oxide (8.8 g, 100 mmol). The mixture was refluxed for 2 days. After cooling to room temperature, the mixture was filtered through Celite, and the filtrate was concentrated. The residue was purified by reverse phase column chromatography (eluting with acetonitrile in water 25% v/v, with 0.01% NH3. H2O) to afford the title compound (0.45 g, 15% yield) as a yellow solid. ESI MS: m/z 147 [M+H]+.
Aufarbeitung
- temperatureThe mixture was refluxed for 2 days
- filtrationthe mixture was filtered through Celite
- concentrationthe filtrate was concentrated
- customThe residue was purified by reverse phase column chromatography (
- washeluting with acetonitrile in water 25% v/v
Quellen und Nachweise
- ORD-Eintrag
- ord-4a19075232f043c2b488e9527d3f5541
- Quelldatensatz
- uspto-grants-2014_07
- Patentnummer
- US08765760B2
Notizen zur Reaktion
Wird geladen…