6-(1H-Indol-4-yl)-1-methyl-4-nitro-1H-indazole → 6-(1H-Indol-4-yl)-1-methyl-1H-indazol-4-amine
Reaktionsgleichung
[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[CH:18]=[C:17]4[C:13]([CH:14]=[N:15][N:16]4[CH3:19])=[C:12]([N+:20]([O-])=O)[CH:11]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1>C(OCC)(=O)C.[Pd]>[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[CH:11]=[C:12]([NH2:20])[C:13]4[CH:14]=[N:15][N:16]([CH3:19])[C:17]=4[CH:18]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
6-(1H-Indol-4-yl)-1-methyl-4-nitro-1H-indazole (49 mg, 0.17 mmol) was dissolved in ethyl acetate (10 ml) and treated with 10% Pd/C (5 mg) then stirred under hydrogen for 2 h before stirring under nitrogen over the weekend. The reaction was filtered through a Celite cartridge, washing with ethyl acetate, then evaporated to dryness to give the title compound (70 mg) as a grey solid.