Dimethylamine → HCID 44539633, Verbindung

HRID 1616028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1616028
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([C:20]3[CH:28]=[CH:27][CH:26]=[C:25]4[C:21]=3[CH:22]=[CH:23][NH:24]4)[CH:17]=[C:16]3[C:12]=2[CH:13]=[N:14][NH:15]3)=[O:9])[C:5](F)=[CH:4][CH:3]=1.[CH3:30][NH:31][CH3:32].CCN(C(C)C)C(C)C>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([C:20]3[CH:28]=[CH:27][CH:26]=[C:25]4[C:21]=3[CH:22]=[CH:23][NH:24]4)[CH:17]=[C:16]3[C:12]=2[CH:13]=[N:14][NH:15]3)=[O:9])[C:5]([N:31]([CH3:32])[CH3:30])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 674DimethylamineHCID 81531DiisopropylethylamineHCID 44540868HCID 44540868, Verbindung

Produkt 1

HCID 44539633HCID 44539633, VerbindungAusbeute 201,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

6-Chloro-3-fluoro-N-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-2-pyridinecarboxamide (188 mg, 0.46 mmol) was placed in a microwave vial and dissolved in THF (4 ml). Dimethylamine (0.463 ml, 0.93 mmol) and DIPEA (0.485 ml) were added and the mixture was heated at 160° C. for 1 h under microwave irradiation. The solvent was removed in vacuo and the yellow residue was dissolved in DCM (10 ml) and washed with water (10 ml). The DCM was removed in vacuo and the solid was dried in vacuo on a high vacuum line to afford the title compound (400 mg) as a yellow solid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. dissolutionthe yellow residue was dissolved in DCM (10 ml)
  3. washwashed with water (10 ml)
  4. customThe DCM was removed in vacuo
  5. customthe solid was dried in vacuo on a high vacuum line

Quellen und Nachweise

ORD-Eintrag
ord-d746b15010074701a5bbe3ffd3df1833
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765743B2

Notizen zur Reaktion

Wird geladen…